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The toxin MPP + can affect TCA by inhibiting mitochondrial KGDHC in PD animal models

Theres no clear understanding of why adequate levels of B12 are associated with a reduced risk of obesity, but there are a few theories 9-11 : B12 may influence how the body stores fat B12 is required for proper muscle protein, and low levels could interfere with recovery Insufficient B12 impairs red blood cell production and interferes with oxygen delivery to muscles Key takeaway: There is some evidence linking low B12 levels to a higher risk of obesity in children, adolescents, and adults, but the evidence is too weak to confirm a relationship

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included subjects who were related